Prenatal Exposure to Lipopolysaccharide Results in Myocardial Fibrosis in Rat Offspring

Prenatal zinc supplementation ameliorates hippocampal astrocytes activation and inflammatory cytokines expression induced by lipopolysaccharide in a rat model of maternal immune activation

Objective: There is evidence that gestational exposure to lipopolysaccharide (LPS) results in fetal zinc deficiency, and eventually neurodevelopmental abnormalities. In this study, we utilized a rat model of maternal immune activation (MIA) to investigate the possible neuroprotective effect of zinc supplementation throughout pregnancy on hippocampal astrocytes activation as well as inflammatory...

Effects of Prenatal Lipopolysaccharide Exposure on Reproductive Activities and Serum Concentrations of Pituitary-Gonadal Hormones in Mice Offspring

Evaluation of the Protective Effect of Astaxanthin Against Undesired Effects of Prenatal Bacterial Lipopolysaccharide (LPS) Exposure on Maternal Behaviors and Neuronal Changes of Adult Male Offspring in NMRI Mice

Background: Prenatal bacterial lipopolysaccharides (LPS) exposure causes damage of the brain and gonadal system.The aim of this study included determination of astaxanthin effect to ameliorate undesired effects of bacterial LPS during fetal period and improve maternal behavior, body weight and length and neural changes in adult male NMRI mice. Methods: Pregnant female mice were divided into fou...

The Effect of Prenatal Exposure to Restraint Stress on Hippocampal Granule Neurons of Adult Rat Offspring

Objective(s) It is well known that prenatal stresses (PS) induce a variety of neurobiological and behavioral alterations, some of them involving the hippocampal formation. This study aimed to determine whether restraint stress influences the neuronal volume and number of granule cells in the hippocampus of adult rat offspring. Materials and Methods Ten Wistar pregnant rats were randomly divi...

The Effect of Noise Pollution Exposure during Pregnancy on Long Term Potentiation Induction in Pyramidal Neurons of Hippocampus CA1 area in Male Rat Offsprings

Background: It is believed that cognitive processing is easily disturbed by incompatible environmental stimulations. Many studies have shown that prenatal stress affects fetal brain development. The aim of this study was to evaluate the effect of noise pollution exposure during conception period on neural activity of hippocampus CA1 area in male rat offspring. Methods: Four groups of rats inclu...